WHAT IS Zoletil™?

Zoletil™ comprises a synergistic balance between Tiletamine & Zolazepam. Tiletamine – a dissociative anesthetic. Zolazepam – a benzodiazepine tranquilizer group of drugs.

RECOMMENDED FOR

– As a sedative (for restraint, diagnostic or painless examination procedures)

– As a sole anesthetic for minor surgeries or in combination with a potent analgesic for major surgeries

– As an induction agent, prior to inhalant anesthesia

WHY CHOOSE ZOLETIL™?

With two proven ingredients, Zoletil™ is a smart option for general anesthesia combining sedation, muscle relaxation, and analgesia in dogs and cats.

Zoletil™ offers peace of mind owing to its rapid onset of action, the smooth recovery process, and wide safety margin.  With the use of Zoletil™ comes the convenience of flexible dosing based on the procedure to be conducted, multiple modes of administration – IV or IM, and the possibility to integrate Zoletil™ into existing anesthetic protocols.

In addition to the 30 years of experience with Zoletil™ in small animal practice, Zoletil™ has versatility and scientific recognition in a plethora of wildlife species.

COMPOSITION

Zoletil™ 50 = One vial of 675 mg freeze-dried powder contains:

Tiletamine (as Hydrochloride)       125 mg

Zolazepam (as Hydrochloride)       125 mg

Excipients                                     qs

ONE VIAL OF 5 ML SOLVENT CONTAINS:

Sterile Water for injections lP       5 ml

ONE ML OF RECONSTITUTED SOLUTION CONTAINS:

Tiletamine (as Hydrochloride)          25 mg

Zolazepam (as Hydrochloride)          25 mg

Zoletil™ 100 = One vial of 970 mg freeze-dried powder contains:

Tiletamine (as Hydrochloride)       250 mg

Zolazepam (as Hydrochloride)       250 mg

Excipients                                     qs

ONE VIAL OF 5 ML SOLVENT CONTAINS:

Sterile Water for injections lP       5 ml

ONE ML OF RECONSTITUTED SOLUTION CONTAINS:

Tiletamine (as Hydrochloride)          50 mg

Zolazepam (as Hydrochloride)          50 mg

DOSAGE & DIRECTIONS FOR USE

Multiple administrations to be avoided and is associated with delayed recovery, but if given, re-administration should only be at 1/3 to ½ of the initial dose, but the total dosage is should not exceed 26.4 mg/kg.

STORAGE

Prior to opening store in a cool & dry place, protect from exposure to light. Post-re-constitution store at 2 to 8°C and use within 24 hours.

SUGGESTIONS

• 12 hours of fasting prior to anaesthesia
• Removal of anti-parasite collars 24 hours prior to anaesthesia
• Anticholinergic drugs (such as Atropine) may be used 15 mins. prior to Zoletil™ administration
• Apneustic breathing may be observed in cats given in IV mode. This abnormality may last for up to 15 mins & then breathing returns to normal. If not, respiratory assistance needs to be provided.
• Eyes remain open and hence should be protected from excessive dryness (especially in major surgeries, a damp cloth can be placed upon the eyes)
• Animal to be placed in a calm environment during the recovery phase

CONTRAINDICATIONS

• Cardiac disease or severe hypertension; respiratory disease; renal, pancreatic, and hepatic insufficiency; head trauma or intracranial tumors
• Caesarean section or in pregnant bitches and queens
• In conjunction with phenothiazine tranquilizers